Protocol to generate two distinct standard-of-care murine glioblastoma models for evaluating novel combination therapies - Centre Eugène Marquis
Article Dans Une Revue STAR Protocols Année : 2024

Protocol to generate two distinct standard-of-care murine glioblastoma models for evaluating novel combination therapies

Résumé

In cancer research, murine models play a crucial role as highly valuable preclinical tools. Here, we present a protocol to generate a murine model of glioblastoma through the direct intracranial injection of tumor cells. We describe steps for cell culture, intracranial implantation, and standard-of-care treatments. We then detail procedures for monitoring tumor growth using bioluminescent imaging. For complete details on the use and execution of this protocol, please refer to Pelizzari-Raymundo et al.

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Cancer
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Dates et versions

hal-04719892 , version 1 (03-10-2024)

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Raphaël Pineau, Pierre Jean Le Reste, Tony Avril, Ulrich Jarry, Eric Chevet, et al.. Protocol to generate two distinct standard-of-care murine glioblastoma models for evaluating novel combination therapies. STAR Protocols, 2024, 5 (3), pp.103304. ⟨10.1016/j.xpro.2024.103304⟩. ⟨hal-04719892⟩
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