Water-Soluble Triarylborane Chromophores for One- and Two-Photon Excited Fluorescence Imaging of Mitochondria in Cells - Université de Bordeaux
Article Dans Une Revue Chemistry - A European Journal Année : 2016

Water-Soluble Triarylborane Chromophores for One- and Two-Photon Excited Fluorescence Imaging of Mitochondria in Cells

Résumé

Three water-soluble tetracationic quadrupolar chromophores comprising two three-coordinate boron π-acceptor groups bridged by thiophene-containing moieties were synthesised for biological imaging applications. Compound 3 containing the bulkier 5-(3,5-Me2C6H2)-2,2′-(C4H2S)2-5′-(3,5-Me2C6H2) bridge is stable over a long period of time, exhibits a high fluorescence quantum yield and strong one- and two-photon absorption (TPA), and has a TPA cross section of 268 GM at 800 nm in water. Confocal laser scanning fluorescence microscopy studies in live cells indicated localisation of the chromophore at the mitochondria; moreover, cytotoxicity measurements proved biocompatibility. Thus, chromophore 3 has excellent potential for one- and two-photon-excited fluorescence imaging of mitochondrial function in cells
Fichier principal
Vignette du fichier
Paper2016_07_19_Revised.pdf (1.42 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03572593 , version 1 (14-10-2024)

Identifiants

Citer

Stefanie Griesbeck, Zuolun Zhang, Marcus Gutmann, Tessa Lühmann, Robert Edkins, et al.. Water-Soluble Triarylborane Chromophores for One- and Two-Photon Excited Fluorescence Imaging of Mitochondria in Cells. Chemistry - A European Journal, 2016, 22 (41), pp.14701-14706. ⟨10.1002/chem.201602639⟩. ⟨hal-03572593⟩
16 Consultations
0 Téléchargements

Altmetric

Partager

More